Immunoblot:

EUROLINE: ANA Profile 3

  • Differentiation of antibodies against cell nuclei (ANA).
  • Indications: Sharp syndrome (MCTD), systemic lupus erythematosus, Sjögren’s syndrome, systemic sclerosis, poly/dermatomyositis, PBC.
  • Serum dilution 1 : 101; conjugate class anti-human IgG, AP-labelled.
  • With the EUROLINE ANA Profile 3, fifteen autoantibodies can be determined: antibodies against nRNP/Sm, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, centromere protein B, PCNA, dsDNA, nucleosomes, histones, ribosomal P-proteins, AMA M2.
  • Antibodies against SS-A are characteristic markers for SLE and Sjögren’s syndrome. In contrast, antibodies against Ro-52 also occur in patients with other autoimmune diseases.
  • Native antigens, purified by affinity chromatography (exception: centromere protein B, PM-Scl, Ro-52, PCNA).
  • Test strips can be automatically incubated and evaluated using the systems EUROBlotOne, EUROBlotMaster and EUROLineScan.

Auto immuneliver profile

 

EUROLINE: Systemic Sclerosis (Nucleoli) Profile

  • Differentiation of systemic sclerosis-associated antibodies against cell-nuclear antigens.
  • Indications: systemic sclerosis (SSc, diffuse and limited form), overlap syn­dromes.
  • Serum dilution 1 : 101, conjugate class anti-human IgG, AP-labelled.
  • With the EUROLINE Systemic Sclerosis Profile (Nucleoli), thirteen autoantibodies can be determined: anti­bodies against Scl-70, CENP A, CENP B, RP11 (RNAP-III), RP155 (RNAP-III), fibrillarin, NOR-90, Th/To, PM-Scl100, PM-Scl75, Ku, PDGFR, Ro-52.
  • Test strips can be automatically incubated and evaluated using the systems EUROBlotOne, EUROBlotMaster und EUROLineScan.

Gangloside profile

EUROLINE: Profile Autoimmune Liver Diseases

  • Differentiation of antibodies in autoimmune liver diseases.
  • Indications: autoimmune hepatitis, primary biliary cirrhosis, overlaps syndromes.
  • Serum dilution 1 : 101, conjugate class anti-human IgG, AP-labelled.
  • With the EUROLINE Profile Autoimmune Liver Diseases, nine autoantibodies can be determined: antibodies against AMA M2, M2-3E (BPO), Sp100, PML, gp210, LKM-1, LC-1, SLA/LP and Ro-52.
  • Test strips can be automatically incubated and evaluated using the systems EUROBlotMaster, EUROBlotOne, and EUROLineScan

 

EUROLINE: Paraneoplastic Neurological Syndromes 12 Ag

Incubated EUROLINE Neuronal Antigens Profile 12 Ag

  • Differentiation of antibodies against neuronal antigens.
  • Indication: paraneoplastic neurologic syndromes (PNS).
  • Serum dilution 1: 101; conjugate class anti-human IgG, AP-labelled.
  • With the EUROLINE Neuronal Antigen Profile 7, twelve autoantibodies can be determined: antibodies against amphiphysin, CV2 (CRMP5), PNMA2 (Ma2/Ta), Ri, Yo, Hu, recoverin, SOX1, Titin, Zic4, GAD65 and Tr (DNER).
  • Test strips can be automatically incubated and evaluated using the systems EUROBlotMaster and EUROLineScan or EUROBlotOne

EUROLINE: ganglioside profiles

  • Determination of autoantibodies against gangliosides for the serological diagnosis of peripheral neuropathies.
  • Membrane strips printed with individual lines of purified, biochemically characterised antigens.
  • Serum dilution 1: 51; conjugate class anti-human IgG, alkaline phosphatase-labelled and anti-human IgM, alkaline phosphatase-labelled.
  • EUROLINE Ganglioside Profiles allow the determination of up to 7 autoantibodies: antibodies against GM1, GM2, GM3, GD1a, GD1b, GT1b and GQ1b.
  • The test strips can be automatically incubated and evaluated using the EUROBlotMaster or EUROBlotOne system and the EUROLineScan programme.

Neuronal ags profile

ANA Profile 3 (15 test parameters): Clinical association & prevalence

Antigens

Disease

Prevalence

 

U1-nRNP

MCTD

SLE

Rheumatoid arthritis

95 – 100 %

15 – 40 %

3 %

Sm

SLE

5 – 40 %

 

SS-A (Ro)

Sjogern’s syndrome

SLE

Neonatal Lupus syndrome

40 – 95 %

20 60 %

100 %

SS-B (La)

Sjogern’s syndrome

SLE

40 – 95 %

10 – 20 %

Scl -70

PSS, diffuse form

25 – 75 %

 

PM-Scl (PM-1)

Poly-/ dermatomyositis / overlap syndrome

PSS, diffuse form

 

50 – 70 %

5 – 10 %

Jo-1

Polymyositis / dermatomyositis

25 – 35 %

Centromeres (CENP.B)

PSS, Limited form

80- 95 %

Cyclin (PCNA)

SLE

3 %

Ds DNA

SLE

60 – 90 %

Nucleosomes

SLE

40 – 70 %

 

Histones

Drug- induced LE

SLE

Rheumatoid Arthritis

95 %

50 %

15 – 50 %

Ribosomal P- proteins

SLE

10 %

AMA-M2

Primary Biliary Liver Cirrhosis

Ø 90 %

 

 

 

Auto Immune profile:

ANA Profile 3

S.Sclerosis

Profile

Autoimmune Liver Profile 2

Myositis Profile 3

ANCA Profile

Neuronal Antigen Profile2

Gangloside

Profile 2

IgM, IgG

nRNP/Sm

SCL-70

AMA M2

Mi-2

Proteinase 3

Amphiphysin

GM1

Sm

CENP A

M2-3E

Ku

MPO

CV2

GM2

SS-A

CENP B

LKM-1

PM-SCL100

Elastase

PNMA2

GM3

Ro-52

RP11

LC-1

PM-SCL75

Cathepsin G

Ma-2 \ Ta

GD1a

SS-B

RP155

SLA\LP

Jo-1

BPI

Ri

GD1b

Scl-70

FIBRILLARIN

 

SRP

Lactoferrin

Yo

GT1b

PM-Scl

NOR90

 

PL-7

 

Hu

GQ1b

Jo-1

Th\To

 

PL-12

 

 

 

CENP B

PM-Scl100

 

EJ

 

 

 

PCNA

PM-Scl75

 

OJ

 

 

 

dsDNA-NcX

Ku

 

Ro-52

 

 

 

nucleosome

PDGFR

 

 

 

 

 

Histones

Ro-52

 

 

 

 

 

Rib.P-prot

 

 

 

 

 

 

AMA M2

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Allergy Profile:

  • Determination of allergen-specific IgE in serum
  • Analysis of sensitizations against inhalation, food and insect venom allergens or cross-reactions  
  • Low amounts of serum sufficient (100-400 µl)
  • Simultaneous detection of specific IgE against up to 54 single allergens within one incubation  
  • Customized profiles: Broad spectrum of indication- and region-specific profiles available
  • Internal CCD marker enables differentiation between true poly-sensitizations and cross-reactivities due to carbohydrates
  • Limited hands-on-time: fast and easy manual processing or highly efficient semi- and fully-automated processing using 

 

EUROBlotOne, EUROBlotMaster and EUROLineScan.

Food & Inhalation Profile :

INHALATION PROFILE

 

FOOD PROFILE

 

(g6, g12, t2, t3, t7, t9, w1, w6, d1, d2, i6,

e1, e2, e3, e17, m1, m2, m3, m5, m6, CCD)

(f1, f75, f2, f105, f4, f14, f45, fs36, f13, f92, f33,

f44, f93, f25, f31, f48, f83, f88, f3, f23, CCD)

g6

Timothy grass (عشب تموثي)

f1

Hens egg white بياض البيض))

g12

Rye (عشب)

f75

Hens egg yolk صفار البيض))

t2

Alder (عشب ألدر)

f2

Cow’s milk proteinالبقر) بروتين لبن)

t3

Birch (شجرة البتولا)

f105

)شوكولاته) Chocolate

t7

Oak (شجرة البلوط)

f4

Wheat flour (دقيق القمح)

t9

Olive (زيتون)

f14

Soybean (فول الصويا)

w1

Ragweed (عشب)

f45

Bakerꞌs yeast S. cerevisiae (خيره الخبز)

w6

Mugwort (عشب الميرميه)

fs36

Nut Mix2 (Pea nut,Hazel nut, almond)

مكسرات البندق واللوز والفول السوداني))

d1

Dermatophagoides pteronyssinus (عت غبار المنزل الاوربيه)

f13

Peanut (الفول السوداني)

d2

Dermatophagoides farina (عت غبار المنزل الامريكيه)

f92

Nutmeg (جوز الطيب)

i6

German cockroach (صرصور)

f33

Orange (برتقال)

e1

Cat epithelium (القط)

f44

Strawberry (فراوله)

e2

Dog hair (الكلب)

f93

Mango (مانجو)

e3

Horse epithelium (حصان)

f25

Tomato (طماطم)

e17

Camel hair + epithelium (الابل)

f31

Carrot (الجزر)

m1

Penicilium notatum (فطر)

f48

Apple (تفاح)

m2

Cladosporium herbarum (فطر)

f83

Chicken (الدجاج)

m3,

Aspergillus fumigates (فطر)

f88

Mutton /Lamb (لحم الضأن)

m5

Candida albicans (فطر)

f3

Codfish (سمك البحر)

m6

Alternaria tenuis (فطر)

f23

Crab ((سرطان البحر

CCD

CCD marker

CCD

CCD marker

s.sclerosis profile